Bleeding and Thrombosis - part I
1 In the human hemostatic system, procoagulant forces include ?
A. Platelet adhesion
B. Platelet aggregation
C. Fibrin clot formation
D. All of the above
2 The major components of the hemostatic system are ?
A. Platelets, monocytes and red cells
B. Plasma proteins
C. Vessel wall
D. All of the above
3 Formed element of blood that is not a component of the hemostatic system is ?
A. Neutrophil
B. Monocyte
C. Red cell
D. Platelet
4 Platelet adhesion is mediated primarily by ?
A. von Willebrand factor (vWF)
B. Gp IIb/IIIa
C. Gp Ia/IIa
D. Fibronectin
5 Which of the following is false about von Willebrand factor (VWF) ?
A. Large multimeric protein
B. Present in plasma
C. Present in extracellular matrix of subendothelial vessel wall
D. None of the above
6 Which of the following is released from activated platelets ?
Harrison’s 18th Ed. 457
A. Epinephrine
B. Thrombin
C. Adenosine diphosphate
D. All of the above
7 Most abundant receptor on the platelet surface is ?
A. Gp Ia/IIa
B. Gp Ib/IX
C. Gp IIb/IIIa
D. Gp VI
8 Platelet surface receptor GpIIB / IIIa binds to ?
A. Thrombospondin
B. Fibrinogen
C. Collagen
D. All of the above
9 Surface of each platelet has how many GpIIb / IIIa binding sites ?
A. ~ 10,000
B. ~ 25,000
C. ~ 50,000
D. ~ 100,000
10 Tissue factor (TF) is present on ?
A. Subendothelial cellular components of vessel wall
B. Circulating microparticles from monocytes
C. Circulating microparticles from platelets
D. All of the above
11 Which of the following is a serine protease factor ?
A. III
B. VIIa
C. IX
D. X
12 Essential cofactor for conversion of prothrombin to thrombin is ?
A. Va
B. VIIa
C. IX
D. X
13 Which of the following in endothelial cells has antithrombotic effect ?
A. Prostacyclin
B. Nitric oxide
C. EctoADPase/CD39
D. All of the above
14 Anticoagulant factor produced by endothelial cells is ?
A. Heparan proteoglycans
B. Antithrombin
C. Thrombomodulin
D. All of the above
15 Which of the following produced by endothelial cells acts as an anticoagulant ?
A. Plasminogen activator inhibitor
B. Thrombomodulin
C. Prostacyclin
D. Nitric oxide
16 Endothelial cells activate fibrinolytic mechanisms through the production of ?
A. Tissue plasminogen activator 1
B. Urokinase
C. Plasminogen activator inhibitor
D. All of the above
17 Which of the following best relates to heparin ?
A. Antithrombin III
B. Protein C
C. Protein S
D. All of the above
18 Which of the following becomes an anticoagulant when it is activated by thrombin ?
A. Antithrombin III
B. Protein C
C. Protein S
D. Tissue factor pathway inhibitor (TFPI)
19 Which of the following about thrombomodulin is false ?
A. Transmembrane proteoglycan binding site for thrombin on endothelial cell surface
B. Thrombin-induced activation of protein C occurs physiologically on thrombomodulin
C. Anticoagulant factor from endothelial cell
D. None of the above
20 Activated protein C acts as an anticoagulant by cleaving and inactivating activated factor ?
A. II
B. V
C. VI
D. X
21 Which of the following relates to protein S ?
A. Cofactor
B. Glycoprotein
C. Vitamin K dependent posttranslational modification
D. All of the above
22 Which of the following inhibits TF / FVIIa / FXa complex ?
A. Activated protein C
B. Protein S
C. Tissue factor pathway inhibitor (TFPI)
D. All of the above
23 Tissue factor pathway inhibitor (TFPI) be released by ?
A. Heparin
B. Streptokinase
C. Urokinase
D. All of the above
24 Plasminogen activators (tPA & uPA) cleave which bond of plasminogen to generate the active enzyme plasmin ?
A. Arg460 - Val461
B. Arg560 - Val561
C. Arg660 - Val661
D. Arg760 - Val761
25 “Fibrin specific” activity of plasmin is due to its ?
A. Arginine-binding sites
B. Lysine-binding sites
C. Valine-binding sites
D. Leucine-binding sites
26 Physiologic regulation of fibrinolysis is done by ?
A. Plasminogen activator inhibitors (PAI-1 & PAI-2)
B. Thrombin-activatable fibrinolysis inhibitor (TAFI)
C. Alpha2-antiplasmin
D. All of the above
27 Which of the following antiplasmin inhibits plasmin ?
A. Alpha1 antiplasmin
B. Alpha2 antiplasmin
C. Alpha3 antiplasmin
D. Alpha4 antiplasmin
28 Epistaxis is the most common symptom in ?
A. Hemophilia A
B. Ehlers-Danlos syndrome
C. Hereditary hemorrhagic telangiectasia
D. Cushing’s syndrome
29 Menorrhagia is a common symptom in women with ?
A. VWD
B. Factor XI deficiency
C. Symptomatic carriers of hemophilia A
D. All of the above
30 Which of the following is called a “life-threatening site of bleeding” ?
A. Bleeding into oropharynx
B. Bleeding into central nervous system
C. Bleeding into retroperitoneum
D. All of the above
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