Bleeding and Thrombosis II

Bleeding and Thrombosis - part II

41 Which of the following about clopidogrel is false ?
A. Thienopyridine
B. Inhibits ADP-mediated platelet aggregation
C. Can precipitate or exacerbate bleeding symptoms
D. None of the above


42 Herb with potential anti-platelet activity is ?
A. Ginger
B. Turmeric
C. Garlic
D. All of the above


43 Which of the following is a Coumarin containing herb ?
A. Motherworth
B. Chamomile
C. Horse chestnut
D. All of the above


44 Bruising or mucosal bleeding may be the presenting complaint in ?
A. Liver disease
B. Severe renal impairment,
C. Hypothyroidism
D. All of the above


45 All coagulation factors are synthesized in ?
A. Liver
B. Kidney
C. Lungs
D. None of the above


46 Which of the following coagulation factors is dependent on vitamin K for posttranslational modification ?
A. Factor II
B. Factor VII
C. Factor IX
D. All of the above


47 Which of the following proteins is dependent on vitamin K for posttranslational modification ?
A. Protein C
B. Protein S
C. Protein Z
D. All of the above


48 Normal blood platelet count is ?
A. 50,000 to 100,000/μL
B. 100,000 to 250,000/μL
C. 150,000 to 450,000/μL
D. 250,000 to 550,000/μL


49 Thrombocytopenia results from ?
A. Decreased production of platelets
B. Increased destruction of platelets
C. Sequestration of platelets
D. Any of the above


50 Bleeding rarely occurs in isolated thrombocytopenia at counts ?
A. < 50000 / μL
B. < 80000 / μL
C. < 100000 / μL
D. < 150000 / μL


51 Most procedures can be performed in patients with a platelet count of ?
A. < 50000 / μL
B. < 80000 / μL
C. < 100000 / μL
D. < 150000 / μL


52 The major risk factor for arterial thrombosis is ?
A. Atherosclerosis
B. Hyperhomocysteinemia
C. Dysfibrinogenemia
D. Hormonal therapy


53 Most coagulation assays are performed in plasma anticoagulated with ?
A. Ethylenediamine tetraacetic acid (EDTA)
B. Sodium citrate
C. Heparin
D. Any of the above


54 PT assesses the factors except ?
A. Factor I
B. Factor II
C. Factor V
D. Factor VIII


55 International normalized ratio (INR) is calculated by ?
A. PT ratio x International Sensitivity Index (ISI)
B. PT ratio ÷ International Sensitivity Index (ISI)
C. PT ratio + International Sensitivity Index (ISI)
D. (PT ratio)International Sensitivity Index (ISI)


56 Activated partial thromboplastin time (aPTT) assesses which of the following factors ?
A. Factor VIII
B. Factor IX
C. Factor X
D. All of the above


57 Structure of Fibrinogen is ?
A. Uninodular
B. Binodular
C. Trinodular
D. Quadrinodular


58 Cross-linking of the D domains on adjacent fibrinogen molecules is done by ?
A. FX
B. FXI
C. FXII
D. FXIIIa


59 Which of the following about D-Dimers is false ?
A. Product of complete lysis of fibrin
B. Released when plasmin acts on fibrin
C. Relatively specific test of fibrin degradation
D. Relatively specific test of fibrinogen degradation


60 Normal level of D-Dimer in blood is ?
A. < 500 pg/mL
B. < 500 ng/mL
C. < 500 μg/mL
D. < 500 mg/mL


71 Plasma level of D-Dimer is ?
A. 0.22 - 0.74 mg/mL
B. 0.22 - 0.74 μg/mL
C. 0.22 - 0.74 ng/mL
D. 0.22 - 0.74 pg/mL


72 D-dimer levels increase in patients with ?
A. Myocardial infarction
B. Pneumonia
C. II or III trimester of pregnancy
D. All of the above


73 Platelet interaction with vascular collagen is stabilized by ?
A. Gp Ia/IIa
B. Gp VI
C. von Willebrand factor (vWF)
D. FcRg


74 Platelet surface receptor GpIb / IX binds to ?
A. vWF
B. Fibrinogen
C. Collagen
D. All of the above


75 vWF forms a link between collagen fibrils & which of the following platelet receptor ?
A. Gp Ia/IIa
B. Gp Ib/IX
C. Gp VI
D. All of the above


76 Formation of thromboxane A2 (TXA2) from arachidonic acid is mediated by enzyme ?
A. Phospholipase C
B. Phospholipase A2
C. Cyclooxygenase
D. All of the above


77 Platelet surface receptor GpIa/IIa binds to ?
A. vWF
B. Fibrinogen
C. Collagen
D. All of the above


78 Platelet surface receptor GpVI / FcRIIa binds to ?
A. vWF
B. Fibrinogen
C. Collagen
D. All of the above


79 After leaving bone marrow, what proportion of platelets are sequestered in spleen ?
A. One-third
B. One-half
C. Two-thirds
D. Three-fourths


80 The life span of platelets in circulation is about ?
A. 1 to 3 days
B. 3 to 5 days
C. 5 to 7 days
D. 7 to 10 days


91 During menstrual cycle, platelet count rise at what time ?
A. Following ovulation
B. At the onset of menses
C. After completion of menstrual flow
D. Before ovulation


92 During menstrual cycle, platelet count fall at what time ?
A. Following ovulation
B. At the onset of menses
C. After completion of menstrual flow
D. Before ovulation


93 Platelet counts are decreased in which of the following deficiencies ?
A. Severe Iron deficiency
B. Folic acid deficiency
C. Vitamin B12 deficiency
D. All of the above


94 Secondary or reactive thrombocytosis is due to which property of platelets ?
A. Hormonal
B. Acute-phase reactant
C. Enzymatic
D. All of the above


95 Which of the following cytokines interleukins stimulate platelet production in acute inflammation ?
A. IL-3
B. IL-6
C. IL-11
D. All of the above


96 Mechanism of thrombocytopenia include ?
A. Decreased bone marrow production
B. Increased splenic sequestration
C. Accelerated destruction
D. All of the above


97 TAR syndrome means ?
A. Thrombocytopenia with absent reticulocytes
B. Thrombocytopenia with absent renin
C. Thrombocytopenia with absent radii
D. Thrombocytopenia with abnormal vessels


98 Acute ITP is common in ?
A. Children
B. Adults
C. Elderly
D. All of the above


99 Which of the following appear in the red cells of asplenic individuals ?
A. Macroovalocytes
B. Basophilic stippling
C. Howell-Jolly bodies
D. Target cells


100 Rituximab is what type of a monoclonal antibody ?
A. Anti-CD19
B. Anti-CD20
C. Anti-CD21
D. Anti-CD22