Asthma

Asthma

1 Which of the following statements about asthma is false ?
A. 10 - 12% adults and 15% children affected by asthma
B. Peak age of presentation is 3 years
C. Sex ratio in adults is equal
D. None of the above


2 Which of the following about asthma is false ?
A. Most patients with asthma in affluent countries are atopic
B. Severity of asthma varies significantly within a patient
C. Onset of asthma in adulthood rarely become permanently asymptomatic
D. Inflammatory disease of airways


3 Asthma is a disease of ?
A. Large airway
B. Medium airway
C. Terminal bronchiole
D. Respiratory bronchiole


4 The term “atopy” in Greek means ?
A. Inert
B. Out of place
C. Explosive
D. Mischief


5 Allergic rhinitis is found in what percentage of asthmatic patients ?
A. ~ 40 %
B. ~ 60 %
C. ~ 80 %
D. ~ 100 %


6 Which of the following is called ‘house-dust mite’ ?
A. Dermatophagoides pteronyssinus
B. Betula verrucosa
C. Phleum pratense
D. Ambrosia artemisiifolia


7 Atopy is due to the genetically determined production of ?
A. IgA antibody
B. IgE antibody
C. IgG antibody
D. IgM antibody


8 Which of the following statements about nonatopic or intrinsicasthma is false ?
A. Negative skin test to common inhalant allergens
B. Normal serum IgE levels
C. Have mild asthma
D. Commonly have nasal polyps


9 Novel gene associated with asthma is ?
A. ADAM-33
B. DPP-10
C. GPRA
D. All of the above


10 Which of the following is strongly linked with asthma in genetic association studies ?
A. TNFAIP3
B. ORMDL3
C. PTPN2
D. IL23R


11 Airway mucosa in asthma is infiltrated with ?
A. Activated eosinophils
B. T lymphocytes
C. Activated mucosal mast cells
D. All of the above


12 In asthma, characteristic histologic finding in airways is ?
A. Normal parenchymal attachments
B. Thickened airway smooth muscle
C. Goblet cell metaplasia
D. Thickening of basement membrane


13 Thickening of basement membrane in airway mucosa due to subepithelial collagen deposition is a feature of ?
A. Atopic asthma
B. Nonatopic asthma
C. Aspirin-sensitive asthma
D. All of the above


14 Which of the following is a histopathologic feature of a small airway in fatal asthma ?
A. Goblet cell aplasia
B. Goblet cell dysplasia
C. Goblet cell metaplasia
D. Any of the above


15 Mast cell is the key effector cell of the biologic response in ?
A. Allergic rhinitis
B. Urticaria
C. Anaphylaxis
D. All of the above


16 Human mast cells originate from ?
A. CD34+
B. CD 4+
C. CD 8+
D. All of the above


17 In asthmatic patients, mast cells are localized to airway ?
A. Epithelial cells
B. Fibroblasts
C. Smooth muscle
D. Parenchyma


18 Activated mast cells are found at the airway surface in ?
A. Asthma patients
B. Normal subjects
C. Patients with eosinophilic bronchitis
D. All of the above


19 Mast cells release which of the following bronchoconstrictor mediators ?
A. Histamine
B. Prostaglandin D2
C. Cysteinyl-leukotrienes
D. All of the above


20 In “sensitization”, IgE gets attached to human mast cells and ?
A. Basophils
B. Eosinophils
C. Monocytes
D. Lymphocytes


21 Bronchial asthma is associated with increased levels of ?
A. Leukotrienes
B. PGI1
C. PGI2
D. Thromboxane


22 Mechanism by which aspirin produces bronchospasm is ?
A. Induction of Haptines
B. Chronic overexcretion of cysteinyl leukotrienes
C. Production of T cell derived cytokines
D. All of the above


23 Which of the following is a cysteinyl leukotriene ?
A. LTC4
B. LTD4
C. LTE4
D. All of the above