Disorders of granulocytes & monocytes
1 Which of the following is a leukocyte ?
A. Natural killer (NK) cell
B. B lymphocyte
C. Monocyte
D. All of the above
2 Which of the following statements about leukocytes is false ?
A. Derived from common stem cell in bone marrow
B. Threefourths of nucleated cells of bone marrow are committed to leukocyte production
C. Their maturation in marrow is regulated by colony stimulating factors & interleukins
D. None of the above
3 Minimum number of stem cells necessary to support hematopoiesis is ?
A. 100 to 200
B. 200 to 300
C. 300 to 400
D. 400 to 500
4 Colony-stimulating factors are produced by ?
A. Monocytes
B. Tissue macrophages
C. Stromal cells
D. All of the above
5 In a 80 kg person, how many neutrophils are produced by hematopoietic system per day ?
A. ~ 0.3 x 1011
B. ~ 1.3 x 1011
C. ~ 2.3 x 1011
D. ~ 3.3 x 1011
6 Maturation from metamyelocyte to neutrophil takes how many days ?
A. 2 days
B. 5 days
C. 7 days
D. 10 days
7 Which of the following is the largest cell in size ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. Metamyelocyte
8 Primary or azurophil granules are present in ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. All of the above
9 Primary or azurophil granules contain ?
A. Hydrolases
B. Cathepsin G
C. Myeloperoxidase
D. All of the above
10 Which of the following azurophil granules has broad antimicrobial activity against bacteria, fungi & certain enveloped viruses ?
A. Hydrolases
B. Cathepsin G
C. Myeloperoxidase
D. Defensins
11 Specific or secondary granules are present in ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. All of the above
12 Secondary granules contain all except ?
A. Acid hydrolases
B. Lactoferrin
C. Vitamin B12 binding protein
D. Histaminase
13 Excessive segmentation of nucleus of neutrophils is a manifestation of ?
A. Folate or vitamin B12 deficiency
B. Iron deficiency
C. Thalassemia
D. Repeated blood transfusion
14 Which of the following is false about ‘Pelger-Huet anomaly’ ?
A. Benign disorder
B. Majority of granulocytes are bilobed
C. Nucleus has spectacle-like configuration
D. None of the above
15 Under normal conditions, what proportion of neutrophil pool is in the bone marrow ?
A. ~ 20 %
B. ~ 50 %
C. ~ 70 %
D. ~ 90 %
16 Under normal conditions, what proportion of neutrophil pool is in the circulation ?
A. ~ 2 %
B. ~ 20 %
C. ~ 50 %
D. ~ 90 %
17 Marginated leukocytes are maximum in ?
A. Lungs
B. Spleen
C. Liver
D. Kidneys
18 “Rolling” of the neutrophil along the endothelial surface is a function of ?
A. Selectins
B. Integrins
C. Intercellular adhesion molecules
D. Opsonins
19 Neutrophils “stick” to the endothelium through ?
A. Selectins
B. Integrins
C. Intercellular adhesion molecules
D. Opsonins
20 Diapedesis involves which of the following ?
A. PECAM 1
B. Anaphylatoxins
C. Vascular endothelial growth factor (VEGF)
D. Prostaglandins E & I
21 In the healthy adult, most neutrophils leave the body by ?
A. Migration through mucous membrane of GI tract
B. Apoptosis
C. Phagocytosis
D. All of the above
22 Normally, neutrophils spend how much time in circulation ?
A. 2 to 3 hours
B. 6 to 7 hours
C. 12 to 24 hours
D. 24 to 36 hours
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